{"id":561722,"date":"2023-06-13T15:34:27","date_gmt":"2023-06-13T19:34:27","guid":{"rendered":"https:\/\/www.rochester.edu\/newscenter\/?p=561722"},"modified":"2023-06-23T12:03:54","modified_gmt":"2023-06-23T16:03:54","slug":"ai-helps-measure-fluid-flow-in-brain-561722","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/","title":{"rendered":"AI helps show how the brain\u2019s fluids flow"},"content":{"rendered":"

New research targets diseases including Alzheimer\u2019s.<\/h2>\n

A new artificial intelligence-based technique for measuring fluid flow around the brain\u2019s blood vessels could have big implications for developing treatments for diseases such as Alzheimer\u2019s.<\/p>\n

The perivascular spaces that surround cerebral blood vessels transport water-like fluids around the brain and help sweep away waste. Alterations in the fluid flow are linked to neurological conditions, including Alzheimer\u2019s, small vessel disease, strokes, and traumatic brain injuries but are difficult to measure in vivo.<\/p>\n

A multidisciplinary team of mechanical engineers, neuroscientists, and computer scientists led by 人妻少妇专区<\/a> Associate Professor Douglas Kelley<\/a> developed novel AI velocimetry measurements to accurately calculate brain fluid flow. The results are outlined in a study published by Proceedings of the National Academy of Sciences<\/em><\/a>.<\/p>\n

\u201cIn this study, we combined some measurements from inside the animal models with a novel AI technique that allowed us to effectively measure things that nobody\u2019s ever been able to measure before,\u201d says Kelley, a faculty member in Rochester\u2019s Department of Mechanical Engineering<\/a>.<\/p>\n

\"Video
A video shows a perivascular space (area within white lines) into which the researchers injected tiny particles. The particles (shown as moving dots) are trailed by lines which indicate their direction. Having measured the position and velocity of the particles over time, the team then integrated this 2D video with physics-informed neural networks to create an unprecedented high-resolution, 3D look at the brain’s fluid flow system. (Douglas Kelley)<\/figcaption><\/figure>\n

The work builds upon years of experiments led by study coauthor Maiken Nedergaard<\/a>, the codirector of Rochester\u2019s Center for Translational Neuromedicine<\/a>. The group has previously been able to conduct two-dimensional studies on the fluid flow in perivascular spaces by injecting tiny particles into the fluid and measuring their position and velocity over time. But scientists needed more complex measurements to understand the full intricacy of the system\u2014and exploring such a vital, fluid system is a challenge.<\/p>\n

To address that challenge, the team collaborated with George Karniadakis from Brown University to leverage artificial intelligence. They integrated the existing 2D data with physics-informed neural networks to create unprecedented high-resolution looks at the system.<\/p>\n

\u201cThis is a way to reveal pressures, forces, and the three-dimensional flow rate with much more accuracy than we can otherwise do,\u201d says Kelley. \u201cThe pressure is important because nobody knows for sure quite what pumping mechanism drives all these flows around the brain yet. This is a new field.\u201d<\/p>\n

The scientists conducted the research with support from the Collaborative Research in Computational Neuroscience program, the National Institutes of Health Brain Initiative, and the Army Research Office\u2019s Multidisciplinary University Research Initiatives program.<\/p>\n

\n

Read more<\/strong><\/h3>\n
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\"IllustrationStudy suggests how high blood pressure might contribute to Alzheimer\u2019s<\/strong><\/a><\/p>\n

New Rochester research may help explain the connection between high blood pressure and Alzheimer\u2019s disease, and it\u2019s all to do with how the brain pumps away waste.<\/span><\/p>\n<\/div>\n

\n

\"MicroscopicGrant will help unlock workings of brain’s waste removal system.<\/strong><\/a><\/p>\n

Rochester scientists discovered the glymphatic system. Now, the National Institutes of Health is bringing together several teams of researchers to better understand its mechanics.<\/span><\/p>\n<\/div>\n

\n

\"WomanNot all sleep is equal when it comes to cleaning the brain.<\/strong><\/a><\/p>\n

New research shows how the depth of sleep can impact our brain\u2019s ability to efficiently wash away waste and toxic proteins, reinforcing the links between aging, sleep deprivation, and heightened risk for Alzheimer\u2019s disease.<\/span><\/p>\n<\/div>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

A new, AI-based technique for measuring fluid flow in the brain could lead to treatments for diseases such as Alzheimer\u2019s.<\/p>\n","protected":false},"author":1242,"featured_media":561832,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[116],"tags":[19162,23312,29752,18632,8366,111,18572],"class_list":["post-561722","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sci-tech","tag-center-for-translational-neuromedicine","tag-department-of-mechanical-engineering","tag-douglas-kelley","tag-hajim-school-of-engineering-and-applied-sciences","tag-maiken-nedergaard","tag-medical-center","tag-research-finding"],"acf":[],"yoast_head":"\nAI helps show how the brain\u2019s fluids flow<\/title>\n<meta name=\"description\" content=\"A new technique for measuring fluid flow in the brain could lead to treatments for diseases such as Alzheimer\u2019s.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AI helps show how the brain\u2019s fluids flow\" \/>\n<meta property=\"og:description\" content=\"A new technique for measuring fluid flow in the brain could lead to treatments for diseases such as Alzheimer\u2019s.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/\" \/>\n<meta property=\"og:site_name\" content=\"News Center\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-13T19:34:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-23T16:03:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2023\/06\/fea-AI-brain-fluid-flows.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Luke Auburn\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Luke Auburn\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/\",\"url\":\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/\",\"name\":\"AI helps show how the brain\u2019s fluids flow\",\"isPartOf\":{\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2023\/06\/fea-AI-brain-fluid-flows.jpg\",\"datePublished\":\"2023-06-13T19:34:27+00:00\",\"dateModified\":\"2023-06-23T16:03:54+00:00\",\"author\":{\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/#\/schema\/person\/e928dc2863b53a89ece6d40c7992a4e1\"},\"description\":\"A new technique for measuring fluid flow in the brain could lead to treatments for diseases such as Alzheimer\u2019s.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.rochester.edu\/newscenter\/ai-helps-measure-fluid-flow-in-brain-561722\/#primaryimage\",\"url\":\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2023\/06\/fea-AI-brain-fluid-flows.jpg\",\"contentUrl\":\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2023\/06\/fea-AI-brain-fluid-flows.jpg\",\"width\":1000,\"height\":600,\"caption\":\"Changes in the brain\u2019s complex fluid flow system are linked to neurological conditions including Alzheimer\u2019s, small vessel disease, strokes, and traumatic brain injuries. 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